Endocrine Abstracts

Introduction: Turner’s syndrome (TS) or Ullrich-Turner’s syndrome is genetic condition that affects only females. It is characterized by typical physical features and complete or part absence of one of the X chromosomes. Women with TS have been reported to be at increased risk of autoimmune diseases as compared with other women. Idiopathic thrombocytopenic purpura (ITP), isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other c...

Ganglioneuromas are benign sympathetic tissue tumors originating from neural crest cells. A 40-year-old female patient, was admitted to our department for endocrinological evaluation of incidentally discovered tumor of right adrenal gland. For about a year before admission she had a pain under the right costal arch. An ultrasound and computed tomography (CT) showed 2 ovoid cystical tumors of right adrenal (34 and 32 mm, respectively). Three months prior admission she had sever...

Introduction: Cushing’s syndrome (CS) results from inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality.Case report: A 38-year-old woman with a typical appearance of CS was admitted for further evaluation of hypercortisolism. The serum cortisol level was elevated without diurnal rhythm, with no adequate supression of cortisol after 1 mg dexamethasone suppresion test. Twenty-four-hour urinary free...

Involutive hypoandria (late onset hypogonadism) is characterized by decline in serum testosterone and increase of gonadotropins. Changes of hypothalamo-pituitary-testicular axis sensitivity are influenced by primary testicular changes and altered neuroendocrine regulation during aging. To evaluate age-related changes in gonadotroph and Leydig cell sensitivity two groups were formed: 1) 35 men, 51.8±3.2 years old, BMI=28.2±3.1 kg/m2; 2) 32 men, 63.2±6....

Introduction: Obesity is often accompanied by comorbidites predisposing atherosclerosis. Carotid intima-media complex thickness (CIMT) is consisdered as a marker of initial asymptomatic atherosclerosis. The relationship of sex hormones to obesity and atherosclerosis has been extensively studied.Objective: The objective of the study was to analyze the correlation CIMT and sex steroid levels in severly obese pre-menopausal women.Meth...

The cholesterol oxidation product 27-hydroxycholesterol (27OHC) is enzymatically produced from cholesterol by CYP27A1 in an alternative pathway of cholesterol degradation to bile acids. This oxysterol also acts as an endogenous selective estrogen receptor modulator (SERM). In healthy humans its concentration in circulation increases in hypercholesterolemia and with age, and is associated with increased risk of atherosclerosis, cardiovascular diseases and breast cancer. Several...

Introduction: The incidence of adrenal incidentaloma (AI) increases with age. According to epidemiological studies they are more frequent in women than in men.Aim: The aim was to determine the possible clinical sexual dimorphism in patients with nonfunctional adrenal incidentaloma (NAI).Patients and methods: This was an observational, cross-sectional study of 381 patients with AI that were functionally assessed in our Clinic. After...

Introduction: Many diseases of the adrenal cortex show a higher prevalence in women than men with incidence increasing with age in both genders.Aim: The aim was to determine the possible sexual dimorphism in patients with adrenal incidentaloma (AI) and (possible) autonomous cortisol secretion ((P)ACS).Methods: This was an observational, cross-sectional study of 381 patients with AI that were functionally assessed in our Clinic. Aft...

Background: Reproductive health is a state of complete physical, mental, and social well-being. So far, there is limited evidence about the consequences of Sars-CoV-2 infection on women’s reproductive health.Aim: To determine the effects of Sars-CoV-2 infection on women’s reproductive health.Methods: We created an anonymous survey about reproductive health and shared it with women of reproductive age between May 2022 and ...

Introduction: Relative adrenal insufficiency (RAI) is common in critically ill patients and is characterized by the normal adrenal reserve for homeostatic demands and inadequate cortisol response in acute stress situations. RAI can also occur in patients with liver cirrhosis, both compensated and decompensated. However, it is often forgotten and difficult to diagnose due to the overlap between clinical symptoms of adrenal insufficiency and decompensated liver disease. Also, hy...